The Canal House, or Het Grachtenhuis, is one of the newest museums to open in Amsterdam. I took a tour one lunch hour and it was pretty good. A little smaller than I imagined it would be, there's only one main floor of exhibition, but it's all beautifully set out.
Word to the wise: buy tickets online. They're cheaper and, more importantly, time coded. Children up to the age of 5 have free admission.
Het Grachtenhuis: Herengracht 386, Amsterdam.